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An amino acid code for protein folding PNAS January 2, 2001 Immediate structural data acquired For numerous proteins supports the next conclusions. The amino acid sequences of proteins can stabilize not just the ultimate indigenous condition but will also a small list of discrete partially folded indigenous-like intermediates. Intermediates are shaped in ways that use as models the cooperative secondary structural elements on the indigenous protein. Before intermediates guide the addition of subsequent models within a technique of sequential stabilization mediated by native-like… Present more Immediate structural details attained For numerous proteins supports the next conclusions. The amino acid sequences of proteins can stabilize not only the final indigenous state and also a little set of discrete partially folded native-like intermediates. Intermediates are shaped in measures that use as models the cooperative secondary structural components on the indigenous protein. Earlier intermediates tutorial the addition of subsequent models inside of a process of sequential stabilization mediated by native-like tertiary interactions. The resulting stepwise self-assembly approach automatically constructs a folding pathway, no matter if linear or branched.
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